Rosario Maria Fiorentino, Ph.D.


Investigator
Mucosal Immunology and Biology Research Center, Mass General Research Institute
Assistant Professor of Pediatrics
Harvard Medical School
PhD University of Naples - Federico II 2001
autism spectrum disorder; blood-brain barrier; host-pathogen interactions; leaky gut; salmonella enterica serovar typhi; schizophrenia; shigella dysenteriae; shigella dysenteriae-1; shigella flexneri; shigella vaccines; tight junctions

Part of the Mucosal Immunology and Biology Research Center, the Laboratory of Rosaria Fiorentino, PhD, at Massachusetts General Hospital studies host-microbe interactions in the context of human immunological response.

The lab is also investigating potential connections between the integrity of the blood-brain barrier and neuroinflammation in autism spectrum disorders and schizophrenia.

Host-Microbe Interaction

The overall objective of the Fiorentino lab is to understand the molecular mechanisms of the host functional and immune response to specific human pathogens, including Salmonella enterica serovar Typhi and Shigella dysenteriae-1.

Through the development of new methodologies, we are interested in studying (in vitro and ex vivo) this interplay between microorganisms and the host to shed light on clinical conditions in which this interplay may lead to disease status.

Gut-Brain Axis in Neurodevelopmental Disorders

We are interested in the study of the blood-brain barrier integrity and function (BBB) and neuroinflammation in Autism Spectrum Disorders (ASD) and schizophrenia.

Our goal is to understand whether a dysfunctional blood-brain barrier, possibly associated with microbial dysbiosis and an abnormal gut function (“leaky” gut), could be implicated in the pathogenesis of these neuropsychiatric disorders.

Our goal is to contribute to the designing and development of targeted and more effective intervention strategies.

Research website Publications
mrfiorentino@mgh.harvard.edu
6176434491

CNY-Building #114
114 16th Street
3504
Charlestown, MA 02129