Director Center for Computational and Integrative Biology, Massachusetts General Hospital

Physician Investigator (CL) Molecular Biology, Massachusetts General Hospital

Kurt J. Isselbacher Professor of Medicine in the Field of Gastroenterology Harvard Medical School

Core Member Broad Institute

Physician Gastroenterology, Massachusetts General Hospital

MD University of Zimbabwe School of Medicine 1986

PhD University of Groningen - Netherlands 2010

adaptor proteins signal transducing; autophagy; card signaling adaptor proteins; carrier proteins; celiac disease; chron's disease; gastrointestinal cancer; gastrointestinal tract; gut microbiome; hepatitis; inflammatory bowel diseases; innate immunity; intestinal mucosa; lysosomes; mucosal immunity; nod/lrr; small molecule libraries; sphingolipids; ulcerative colitis

The Xavier Laboratory at the Massachusetts General Hospital and Broad Institute focuses on systematic characterization of genetic variants to understand the regulation of barrier defense, innate and adaptive immunity; chemical biology to control cellular disease phenotypes suggested by human genetics; molecular functions of the microbiome to determine impacts on health and disease; and development of prediction algorithms to identify immunodominant antigens that drive pathogenic and homeostatic T cell responses.