Ramnik Xavier, M.D., Ph.D.


Director
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital
Director
Center for Computational and Integrative Biology, Massachusetts General Hospital
Physician Investigator (Cl)
Center for Computational and Integrative Biology, Mass General Research Institute
Kurt J. Isselbacher Professor of Medicine in the Field of Gastroenterology
Harvard Medical School
Institute Member
Broad Institute
Physician
Gastroenterology, Massachusetts General Hospital
MD University of Zimbabwe School of Medicine 1986
PhD University of Groningen - Netherlands 2010
adaptor proteins signal transducing; autophagy; card signaling adaptor proteins; carrier proteins; celiac disease; crohn disease; gastrointestinal cancer; gastrointestinal tract; gut microbiome; hepatitis; inflammatory bowel diseases; innate immunity; intestinal mucosa; lysosomes; mucosal immunity; nod/lrr; small molecule libraries; sphingolipids; ulcerative colitis

The overall goal of the Xavier laboratory is to understand the function of mediators and effectors involved in innate and adaptive immunity. A second major focus is to understand the function of genes associated with Crohn's disease/ulcerative colitis and risk of autoimmunity using genomics, computational tools and model systems. Recent findings in the laboratory have contributed to elucidating the role of autophagy in Crohn's disease and the discovery of novel immune regulatory genes. In future studies, Dr. Xavier's team hopes to gain insights into the cell-cell interactions and regulatory networks that define functional modules at the host cell-microbe interface in the intestinal mucosa.