Pediatrician Pediatric-Pediatric Cardiology, Massachusetts General Hospital

Associate Professor of Medicine Harvard Medical School

Associate Member Broad Institute

Clinicn Investigator, Assc Prf HVI CV MGH CVM PO, Mass General Research Institute

M.D.; Ph.D. University of Virginia School of Medicine 2003

active transport cell nucleus; aneurysm dissecting; aortic aneurysm; aortic aneurysm thoracic; aortic dissection; aortic rupture; cardiovascular abnormalities; caspases; chemokine ccl5; interleukin-8; karyopherins; marfan syndrome; nuclear pore; nucleocytoplasmic transport proteins; respiratory mucosa; smad4 protein; transforming growth factor beta2 Our laboratory is primarily interested in the clinical expression and molecular etiology of human aortic aneurysm. Aneurysm represents the anatomic expression of aortic organ failure with dilation and eventual tear; an event termed “dissection” associated with high mortality. In our research we use human and murine genetics as well as animal modeling to investigate the etiology and pathologic progression of inherited and sporadic aortic disease. Through our findings we hope to discover better diagnostics and novel therapies for patients with aneurysmal conditions.