Josephine Lok, M.D.
Physician Investigator (Cl)
Pediatric Intensive Care Unit, Research Institute
Pediatric Intensive Care Unit, Massachusetts General Hospital
|MD Albert Einstein college of medicine 1988|
|MD Albert Einstein College of Medicine, of Yeshiva University 1988|
My goals were to 1) determine whether NRG1 plays significant roles in the biology of brain microvascular endothelial cells; and 2) to investigate the neuroprotective potential of NRG1 in brain trauma.
Data from my experiments demonstrated that NRG1 has key functions in brain microvascular cells; in particular, NRG1 prevents endothelial hyper-permeability due to cytokine injury, a significant finding given the many pathological processes that stem from microvascular hyper-permeability during CNS and systemic illness.