Nitya Jain, Ph.D.
Mucosal Immunology and Biology Research Center, Mass General Research Institute
Assistant Professor of Pediatrics
Harvard Medical School
|PhD University of Massachusetts Medical School 2009|
Microbiota and Immune System Development
We are interested in determining the impact of postnatal intestinal microbial colonization on developmental events in the distally located thymus. Specifically, we are investigating which developmental pathways are impacted by intestinal microbiota and what are the mechanisms of thymic-intestine crosstalk.
Vitamin D and Early-Life Immunity
Vitamin D regulates several aspects of immune function as well as the intestinal microbial composition. We are interested in understanding the link between Vitamin D, the postnatal microbiota and early immune development. We are particularly interested in the role of the nuclear receptor RXRA in regulating the Vitamin D response in developing immune cells.