Investigator, Instructor (M) Nephrology, Mass General Research Institute

Instructor in Medicine Harvard Medical School

Assistant Director of the Nikon Center of Excellence at CNY Massachusetts General Hospital

Ph.D in Pharmacology University of Illinois at Chicago 2008

M.S. in Pharmacology Medical College of Ohio 2001

B.S. in Biology Bowling Green State University 1997

5-lipoxygenase-activating proteins; arachidonate 5-lipoxygenase; biochemistry; eicosanoids; fatty acid binding proteins; gpcr signaling; microscopy; molecular imaging; multiprotein complexes; nuclear envelope; nuclear membrane We aim to understand how GPCR signaling is integrated with other signaling pathways to generate bioactive signaling lipids, the leukotrienes (LTs) in myeloid cells. These studies combine biochemistry and molecular imaging to study novel complexes that are assembled on the nuclear envelope to initiate LT synthesis. Because they are transiently assembled complexes held together by weak interactions, we combine multiple biochemical and molecular imaging approaches that include Fluorescence Lifetime Imaging Microscopy (FLIM) and super resolution microscopy (STORM) paired with computational analyses. We have opened a Nikon Center of Excellence and have established collaborations within and outside of Massachusetts General Hospital in the fields of immunology, cell biology and nephrology. We are also in collaboration with the Vasculitis and Glomerulonephritis Center at Mass General where we are studying the organization of the leukotriene synthetic complex in neutrophils from patients with AAV.