Physician Investigator (Cl) Pulmonary, Mass General Research Institute

Assistant Professor of Medicine Harvard Medical School

Assistant Physician Medicine-Pulmonary and Critical Care Medicine, Massachusetts General Hospital

MD University of Chicago Pritzker School of Medicine 2006

actin; acute lung injury; cytoskeleton; endothelial cells; fibroplasts; pulmonary fibrosis Dr. Knipe’s research focuses on understanding the mechanisms driving the development of pulmonary fibrosis. In particular, she utilizes mouse models and explanted tissue from IPF patients undergoing lung transplant to study the role that the actin cytoskeleton plays in multiple cell types to drive pulmonary fibrosis. Dr. Knipe is especially interested in endothelial cell contributions to pulmonary fibrosis, and she is currently studying the role of the cytoskeleton in regulating endothelial barrier function and how vascular permeability relates to fibrosis. However, she is also interested in the role of the cytoskeleton in epithelial cell and fibroblast contributions. Her work may lead to new investigations into the role of the cytoskeleton in acute lung injury as well. Dr. Knipe is affiliated with the Division of Pulmonary and Critical Care Medicine and the Center for Immunology and Inflammatory Diseases at MGH.