Associate Physician Cardiology, Massachusetts General Hospital

Physician Investigator (Cl) Cardiovascular Research Center, Mass General Research Institute

Associate Professor of Medicine Harvard Medical School

Director of Preventive Cardiology Massachusetts General Hospital

MMSc 2015

MD University of California, San Francisco School of Medicine 2008

anti-inflammatory agents; apolipoprotein a-i; cardiovascular genetics; influenza human; influenza vaccines; lipid management; lipoproteins hdl; medical staff hospital; preventative cardiology; proteomics

Dr. Pradeep Natarajan is a preventive cardiologist, cardiovascular geneticist, and physician-scientist. He is the Director of Preventive Cardiology at Massachusetts General Hospital.

Coronary heart disease is a major cause of morbidity and morbidity worldwide. We use naturally-occuring human genetic variation, biomedical informatics, integrative genomics, and genotype-based deeper phenotyping to gain insights about cardiometabolic traits. We use the following approaches to use human genetic variation to understand human disease:

1. Identify causal factors that influence disease
2. Test epidemiological associations for causal inference
3. Disease risk prediction
4. Therapeutic response prediction
5. Discover and characterize the range of phenotypic consequences of putative therapeutic targets.

Such analyses are done through clinical recruitment, family-based studies, observational prospective cohorts, case-control cohorts, large-scale health-care associated biobanks, and randomized controlled clinical trials. We aim to leverage novel insights to improve preventive cardiovascular care.

Dr. Natarajan received his B.A. in Molecular & Cell Biology from the University of California, Berkeley (2004), M.D. from the University of California, San Francisco (2008), and M.M.Sc. in Biomedical Informatics from Harvard Medical School (2015). He completed internship and residency in Internal Medicine at Brigham & Women’s Hospital (2011) and cardiovascular diseases fellowship at Massachusetts General Hospital (2015). He completed post-doctoral training in human genetics at the Massachusetts General Hospital and Broad Institute of Harvard & MIT.