Associate Professor of Medicine Harvard Medical School

Physician Infectious Disease, Massachusetts General Hospital

Clinicn Investigator, Assc Prf Infectious Disease, Mass General Research Institute

MD 2003

antibodies bacterial; antigens bacterial; bacteremia; bacterial proteins; cholera; cholera vaccines; enteric fever; host-pathogen interactions; immunogenic antigens; salmonella typhi; salmonella typhimurium; typhoid fever; vaccine development; vibrio cholerae o1 My laboratory is focused on decreasing the global burden of mucosal and enteric infections of import affecting resource-limited and marginalized populations.  I work in a multi center collaborative effort with investigators at the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b),Partners In Health, and MGH-Harvard that has been focused on broadening our understanding of host-pathogen and immune responses during human infection by V.cholerae (the cause of cholera) and Salmonellaenterica serovar Typhi (the primary causes of enteric fever).  Together, these organisms infect over 25 million individuals and kills over 300,000 individuals each year.  Work in my laboratory has:

1. included application of high-throughput proteomic and genomic platform technologies to identify immunogenic antigens for vaccine and diagnostic development and
2. characterization of immune responses during human infection and vaccination with enteric infections