Jeannie Lee, M.D., Ph.D.

Department of Molecular Biology, Massachusetts General Hospital
Chair, Molecular Biology
M_MOLBIO FACULTY, Massachusetts General Hospital
Professor of Genetics
Harvard Medical School
Howard Hughes Medical Institute
Affiliate Faculty
Harvard Stem Cell Institute
Associate Member
Broad Institute
chromatin; chromatin modifiers; dosage compensation genetic; epigenesis genetic; epigenetics; genomic imprinting; lncrnas; long non-coding rnas; muscular dystrophy; rett syndrome; rna long untranslated; rna untranslated; transcriptomes; x chromosome; x chromosome inactivation; x-inactivation center; xci

Researchers in the Lee Lab use state-of-the-art technologies in molecular biology, biochemistry, cell biology, and embryology to understand how one X-chromosome is turned off in the female but not in the male.

Our lab studies how male (XY) and female (XX) cells use a mechanism called X-chromosome inactivation to achieve equality of sex chromosome gene expression.

Our studies are focused on three noncoding RNA loci whose actions coordinate the many steps of X-chromosome inactivation. We are also interested in the mechanistic and evolutionary relationship between X- inactivation and imprinting. Recent work by the Lee Lab suggests that imprinted X-chromosome inactivation is directly connected to meiotic sex chromosome inactivation in the male germ line.

Research lab website Publications

Simches Building
185 Cambridge Street
Boston, MA 02114