Marcia Goldberg, M.D.

Physician Investigator (Cl)
Infectious Disease, Mass General Research Institute
Infectious Disease, Massachusetts General Hospital
Office of Research Careers, Center for Faculty Development, Massachusetts General Hospital
Professor of Medicine
Harvard Medical School
Associate Member
Broad Institute
MD Harvard Medical School 1984
actins; bacterial outer membrane proteins; bacterial proteins; covid-19; dysentery bacillary; escherichia coli; escherichia coli proteins; innate immunity; sepsis; shigella; shigella flexneri
Pathogenic bacteria promote infection largely through proteins and protein complexes they secrete and deliver into human cells or which alter cell signaling via binding to cell surface molecules. Bacterial molecules that interact with cells trigger human cell-type specific responses that are designed to restrict the infection. Our focus is to understand (1) the function of these secreted and delivered bacterial proteins, particularly during infection by Shigella and other gram-negative bacterial pathogens, (2) the mechanisms of cellular responses, particularly for epithelial cells, macrophages, and endothelial cells, and (3) how host organismic responses go awry, particularly during bacterial sepsis and COVID-19.
Research lab website Publications Clinical Profile
(617) 525-4820
Infectious Disease
Harvard Institutes of Medicine
4 Blackfan Circle,
8th floor / Room 847
Boston, MA 02115-5713