Katia Georgopoulos, Ph.D.


Investigator
Cutaneous Biology Research Center, Mass General Research Institute
Professor of Dermatology
Harvard Medical School
Jean and Terry de Gunzberg MGH Research Scholar 2014-2019
Mass General Research Institute, Massachusetts General Hospital
PhD Newcastle University 1984
chromatin; dna-binding proteins; epithelial disorders; hematopoietic malignancies; hematopoietic stem cells; hemolymphopoiesis; ikaros dna binding factors; ikaros transcription factor; lymphocytes; neoplastic transformation; precursor cells b-lymphoid; transcription factors
Our laboratory's major goal is to understand how multipotent progenitors of the hematopoietic and epithelial systems utilize diverse programs in gene expression to achieve distinct fates in cellular differentiation.

A key aspect of our studies is the epigenetic regulation of gene expression programs as guided by the family of the Ikaros DNA binding factors in concert with specific chromatin regulators.

Elimination of Ikaros function in the early hematopoietic system prevents the generation of an adaptive immune system, whereas loss of Ikaros after specification into the lymphoid lineage leads to the development of aggressive lymphoid leukemias.
 
Loss of function of Ikaros’ chromatin remodeling associates in the skin interferes with the maintenance and differentiation of epidermal and follicular stem cells in unexpected ways. Both aspects of normal development and neoplastic transformation are studied here using state-of-the-art mouse genetic models, cell isolation and differentiation systems combined with comparative global transcriptome and epigenome approaches.
 
These studies benefit our understanding of normal developmental processes and how these are subverted during neoplastic transformation. They provide opportunity for novel treatments of hematopoietic malignancies and epithelial disorders.
Research lab website Publications
katia.georgopoulos@cbrc2.mgh.harvard.edu
6177264445
Cutaneous Biology Research Center
CNY-Building #149
149 13th Street
Charlestown, MA 02129-2000