Katia Georgopoulos, Ph.D.
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Investigator, Full Prof (M) Cutaneous Biology Research Center, Mass General Research Institute |
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Professor of Dermatology Harvard Medical School |
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Jean and Terry de Gunzberg MGH Research Scholar 2014-2019 Mass General Research Institute, Massachusetts General Hospital |
Research Interests
Research Narrative
Our laboratory's major goal is to understand how multipotent progenitors of the hematopoietic and epithelial systems utilize diverse programs in gene expression to achieve distinct fates in cellular differentiation.
A key aspect of our studies is the epigenetic regulation of gene expression programs as guided by the family of the Ikaros DNA binding factors in concert with specific chromatin regulators.
Elimination of Ikaros function in the early hematopoietic system prevents the generation of an adaptive immune system, whereas loss of Ikaros after specification into the lymphoid lineage leads to the development of aggressive lymphoid leukemias.
A key aspect of our studies is the epigenetic regulation of gene expression programs as guided by the family of the Ikaros DNA binding factors in concert with specific chromatin regulators.
Elimination of Ikaros function in the early hematopoietic system prevents the generation of an adaptive immune system, whereas loss of Ikaros after specification into the lymphoid lineage leads to the development of aggressive lymphoid leukemias.
Loss of function of Ikaros’ chromatin remodeling associates in the skin interferes with the maintenance and differentiation of epidermal and follicular stem cells in unexpected ways. Both aspects of normal development and neoplastic transformation are studied here using state-of-the-art mouse genetic models, cell isolation and differentiation systems combined with comparative global transcriptome and epigenome approaches.
These studies benefit our understanding of normal developmental processes and how these are subverted during neoplastic transformation. They provide opportunity for novel treatments of hematopoietic malignancies and epithelial disorders.
Research lab website
Publications
| katia.georgopoulos@cbrc2.mgh.harvard.edu |
| 6177264445 |
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Cutaneous Biology Research Center CNY-Building #149 149 13th Street Charlestown, MA 02129-2000 |