Sareh Parangi, M.D.

Physician Investigator (Cl)
Surgery, Mass General Research Institute
Professor of Surgery
Harvard Medical School
Visiting Surgeon
General and GI Surgery, Massachusetts General Hospital
MD Columbia University College of Physicians & Surgeons 1990
MD Columbia University College of Physicians and Surgeons** 1990
braf; indoles; laryngoplasty; map kinase signaling system; proto-oncogene proteins b-raf; sulfonamides; thrombospondin 1; thyroid carcinoma; thyroid neoplasms; thyroid nodule; thyroidectomy; women in medicine

Dr. Sareh Parangi has been one of the Boston surgeons named in Best Doctor and her excellence in both research and her clinical expertise have earned her a national reputation.

She is one of a handful of thyroid surgeons with expertise in molecular biology and has over 70 publications, many on thyroid cancer therapeutics in premier journal. She has taught about thyroid cancer care at the Harvard Course "Advances in Cancer Management for the Surgeon" and about thyroid and parathyroid ultrasound at the American College of Surgeons.

Dr. Parangi has been able to balance her passion for translational research with innovative and compassionate care to patients with complex thyroid diseases.  Her work in thyroid cancer details certain key genetic changes seen more frequently in those who do poorly, to help elucidate the role of these genetic changes in the aggressive behavior of those cancers.

This important research effort focuses on clarifying the molecular mechanism of thyroid cancer invasion and understanding the process of disease progression in patients with thyroid cancer.

Dr. Parangi's laboratory has started to characterize how a common genetic mutation in aggressive thyroid cancer BRAF (V600E) leads to thyroid cancer cell invasion, migration and metastasis.

She has established the endocrine tumor tissue repository in 2008 and the molecular diagnostics laboratory is has been combined with other translational research efforts at the MGH including the Endocrine Surgery Clinical Database under the auspices of the Codman Center for Clinical Effectiveness and basic science laboratory research to improve translational research in thyroid cancer.