Professor of Anaesthesia Harvard Medical School

Nathaniel M Sims MGH Endowed Chair in Anesthesia Research, Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital

Investigator, Center for Genomic Medicine, Massachusetts General Hospital

Phyllis and Jerome Lyle Rappaport MGH Research Scholar Massachusetts General Hospital

Associate Member Broad Institute

PhD MIT

circadian rhythms; human genetics; long covid; maternal cardiometabolic disease risk; melatonin; preeclampsia; sleep; sleep disorders circadian rhythm

Our lab’s research focuses on:

1) illuminating biological mechanisms underlying inter-individual differences in circadian rhythm and sleep phenotypes and disorders,

2) understanding mechanistic links between sleep/circadian rhythms and diseases, including current projects on:

• circadian rhythms, melatonin and type 2 diabetes
• sleep phsyiology and pre-clinical alzheimers disease
• insomnia and cardiovascular disease
• neurofibromatosis type 1 and sleep
• sleep, long covid and chronic fatigue syndrome

3) identifying pathophysiological mechanisms underlying the adverse pregnancy outcome, preeclampsia and how  impact future maternal cardiovascular disease. 

Our translational research program and collaborative research integrates genome-wide human genetic and multi-omic approaches with focused mechanistic investigation and clinical translational studies.