Jianren Mao, M.D., Ph.D.
Physician Investigator (Cl)
Anes. Research - Monthly, Research Institute
Richard J. Kitz Professor of Anaesthesia Research
Harvard Medical School
Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
|PhD Medical College of Virginia 1992|
|MD Suzhou Medical College 1983|
Our research group focuses on studying the neural and molecular mechanisms of pain and opioid tolerance. We are particularly interested in investigating the interaction between pathological pain and paradoxical pain sensitivity resulting from opioid administration. The group also has access to patients with acute and chronic pain on opioid therapy and actively involves in translational pain research in these areas.
The techniques used in the group include behavioral and pharmacological assessment, immunohistochemistry, autoradiographic receptor binding and amino acid reuptake assay, HPLC assay, cell culture, conventional molecular biology techniques, and ELISA.
The following is a list of ongoing projects in the group:
1. Neuronal apoptosis induced by chronic opioid administration;
2. Intracellular mechanisms underlying opioid-induced neuronal apoptosis;
3. Role of central cannabinoid receptors in the cellular mechanisms of neuropathic pain and their signal transduction pathways;
4. Role of the central glutamatergic system in the cellular mechanisms of neuropathic pain and its interaction with the central cannabinoid system;
5. Opioid-induced abnormal pain sensitivity and its cellular mechanisms;
6. Translational pain research with an emphasis on neuropathic pain and opioid tolerance.