Meghan Sise, M.D.

Physician Investigator (Cl)
Nephrology, Mass General Research Institute
Associate Professor of Medicine
Harvard Medical School
Assistant Physician
Nephrology, Massachusetts General Hospital
MD Columbia University College of Physicians and Surgeons** 2009
MD Columbia University College of Physicians & Surgeons 2009
acute kidney injury; chronic kidney disease; clinical trials; glomerulonephritis; hcv; hepatitis c; hiv; immune checkpoint blockade; immunosuppression; kidney diseases; lupus nephritis; nephritis interstitial; pharmaco-epidemiology

I received my medical degree and biostatistical training at Columbia University College of Physicians and Surgeons and the Mailman School of Public Health. I am the Director of Onconephrology at Massachusetts General Hospital (MGH) and an Associate Professor of Medicine at Harvard Medical School. I currently hold a faculty appointment at MGH in the Division of Nephrology with 75% of my time dedicated to research and I maintain an active clinical presence with 25% clinical effort split between the MGH Bigelow service, inpatient renal consults, and an outpatient clinic at MGH Renal Associates.

My lab is focused on three areas.

1. Onconephrology - the study of how cancer and cancer therapies affect kidney function, with a particular focus on the side effects of cancer immunotherapy.
2. Viruses and the kidney -  determining the impact and mechanism of Hepatitis C Virus (HCV), human immunodeficiency virus (HIV), and COVID-19 on the progression of chronic kidney disease.
3. Clinical Trials in glomerulonephritis (IgA nephropathy, lupus nephritis, MGPN, monoclonal gammopathy of renal significance).

I have focused on the safety and efficacy of novel antivirals and cancer therapies in patients with chronic kidney disease and end-stage renal disease on dialysis. I conduct clinical trials and longitudinal observational pharmaco-epi studies in patients with kidney disease. I conduct translational investigation to better understand the mechanism of acute interstitial nephritis triggered by immune checkpoint inhibitors for cancer. I study the impact of sarcopenia (muscle loss) on estimates of kidney function in patients with cancer.

Visit my lab website:

Research website Publications Clinical Profile

Charles River Plaza East
165 Cambridge Street
Boston, MA 02114