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Guillermo Tearney, M.D., Ph.D.

Wellman Center for Photomedicine, Massachusetts General Hospital
Professor of Pathology
Harvard Medical School
Remondi Family Endowed MGH Research Institute Chair
Massachusetts General Hospital
Mike and Sue Hazard Family MGH Research Scholar
Massachusetts General Hospital
Research lab website
Wellman Center for Photomedicine
Bartlett Extension
40R Blossom Street
Boston, MA 02114

MD Harvard Medical School 1998
PhD Massachusetts Institute of Technology 1997
coronary artery disease; coronary vessels; fiber optic technology; image enhancement; interferometry; lasers; microscopy, confocal; spectrometry, fluorescence; tomography; tomography, optical coherence Dr. Tearney’s research interests are focused on the development and clinical validation of non-invasive, high-resolution optical imaging methods for disease diagnosis. Dr. Tearney's lab was the first to perform human imaging in the coronary arteries and gastrointestinal tract in vivo with Optical Coherence Tomography (OCT), which provides cross-sectional images of tissue architectural microstructure at a resolution of 10 μm. He has also conducted many of the seminal studies validating OCT and is considered an expert on OCT image interpretation.

Recently, Dr. Tearney's lab has invented a next generation OCT technology, termed μOCT, which has a resolution of 1 μm and is capable of imaging cells and sub cellular structures in the coronary wall.

Dr. Tearney has also developed several other technologies, including a confocal endomicroscope capable of imaging the entire esophagus, an ultraminiature three-dimensional endoscope, a highly efficient form of near field scanning optical microscopy (NSOM), and novel fluorescence spectroscopy and multimodality imaging techniques. He has an active program in Raman spectroscopy and has conducted the first intracoronary Raman in vivo.

Dr. Tearney is co-editor of The Handbook of Optical Coherence Tomography and has written over 170 peer-reviewed publications, including papers that have been highlighted on the covers of Science, Nature Medicine, Circulation, Gastroenterology, and Journal of American College of Cardiology.

Dr. Tearney’s work extends beyond his laboratory at MGH, many of his technologies are being produced commercially and he has founded the International Working Group on Intracoronary OCT Standardization and Validation, a group that is dedicated to establishing standards to ensure the widespread adoption of this imaging technology.