John L Niles, M.D.


Physician Investigator (Cl)
Renal Associates Monthly, Mass General Research Institute
Assistant Professor of Medicine
Harvard Medical School
Assistant Physician
Medicine-Nephrology, Massachusetts General Hospital
MD Oregon Health & Science University School of Medicine 1981
anti-neutrophil cytoplasmic antibody-associated vasculitis; antibodies antineutrophil cytoplasmic; antibodies monoclonal; c-anca protein; murine-derived; peroxidase; vasculitis; wegener granulomatosis Dr. Niles was the first to identify the C-ANCA protein, has developed assays for ANCA and has worked with ANCA associated vasculitis since 1988.  He has run numerous clinical studies characterizing the ANCA tests, the disease spectrum associated with ANCA and responses to treatment for ANCA associated disease. Continuous venovenous hemofiltration. Dr. Niles has worked with continuous renal replacement therapies since 1986. He developed and reported a simplified and safer method for using citrate anticoagulation with CVVH.