William Brugge, M.D.
Physician Investigator (NonCl)
Gastroenterology, Mass General Research Institute
Gastroenterology, Massachusetts General Hospital
|MD Baylor College of Medicine 1974|
Our program has developed a variety of endoscopic techniques to aspirate malignant and pre-malignant lesions of the pancreas. These lesions include cystadenomas, intra-ductal tumors, and masses.
We have worked closely with collaborators in the MGH Departments of Cytology and Chemistry to develop assays for tumor markers and cytologic analysis that are capable of making a tissue diagnosis of a mucinous cystadenoma and detecting early evidence of malignant degeneration.
Recently, we have established an endoscopic technique for the diagnosis of early malignancy of the esophagus, often in the setting of Barrett's esophagus. Endoscopic confocal laser microscopy is a new technique for providing histologic quality imaging of the mucosa. We are participating in a national study for establishing the sensitivity and specificity of confocal laser microscopy in Barrett's esophagus.