Alberto Serrano-Pozo, M.D.

Physician Investigator (Cl)
MemMov - Mnthly, Mass General Research Institute
Assistant In Neurology
Massachusetts General Hospital
Instructor in Neurology
Harvard Medical School
MD University of Mlaga-Spain 2001
alzheimer's disease; astrocytes; brain; brain stem infarctions; gliosis; microglia; neurites; neurodegenerative diseases; neurofibrillary tangles; neurology; plaque amyloid; red nucleus; simvastatin; tau proteins I am a clinician-scientist neurologist with interest in Alzheimer’s disease and other neurodegenerative dementias. My research focuses on trying to explain how the amyloid plaques and neurofibrillary tangles accumulate in the brain of Alzheimer’s disease patients and how they lead to dementia. I first approached this question by studying postmortem brain specimens from Alzheimer’s disease patients and healthy individuals under the microscope. The findings of my unbiased quantitative analyses supported an important role of glial (non-neuronal) cells, specifically astrocytes and microglial cells. These cells clearly react to plaques and tangles, but the consequences of this response remain largely unknown. Therefore, I became interested in understanding the underlying mechanisms of glial responses and their effects on Alzheimer’s disease development and progression.