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Andrea Edlow, M.D.

Physician Investigator (Cl)
Vincent Center for Reproductive Biology, Massachusetts General Hospital
Assistant Professor of Obstetrics, Gynecology and Reproductive Biology
Obstetrics Gynecology & Repro. Bio. , Harvard Medical School
Assistant In Gynecology & Obstetrics
Obstetrics & Gynecology, Massachusetts General Hospital
Research website
Vincent Center for Reproductive Biology
Thier Building
60 Blossom Street
Boston, MA 02114-3104

MD Perelman School of Medicine @ University of Pennsylvania 2007
abortion spontaneous; amniotic fluid supernatant; catecholamine neurotransmitter signaling; embryonic brain development; fetal brain development; maternal behavior; maternal diet; obesity; postpartum period; pre-eclampsia; pregnancy trimester second; premature birth

Dr. Andrea Edlow is a member of the Obstetrics and Gynecology faculty at Harvard Medical School and a Maternal-Fetal Medicine specialist at Massachusetts General Hospital. 

The Edlow laboratory focuses on the effects of maternal obesity on fetal brain development and offspring behavior, and how these effects are modified by fetal sex.

The Edlow lab was one of the first to use amniotic fluid supernatant and umbilical cord blood to investigate real-time fetal brain development in obese human pregnancy.

Gene expression profiling of these two biofluids identified abnormal gene expression signatures in fetuses of obese women, highlighting dysregulated brain development and increased inflammation.

Using a validated mouse model of maternal diet-induced obesity, we have demonstrated significant sex differences in the impact of maternal obesity on embryonic brain development, catecholamine neurotransmitter signaling, and offspring neurobehavior.

Maternal diet during pregnancy and lactation also significantly influences in utero brain development and offspring behavior. 

Ultimately, we anticipate this work will provide targets for a lifestyle/behavioral intervention, and possibly for prenatal therapies that could be given orally to obese pregnant women, to reverse or ameliorate deleterious structural and functional brain changes.

Dr. Edlow’s research is funded by the Reproductive Scientist Development Program, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the Burroughs Wellcome Fund, the March of Dimes, and the American Congress of Obstetricians and Gynecologists.