Steven Arnold, M.D.

Physician Investigator (Cl)
Neurology, Mass General Research Institute
Professor of Neurology
Harvard Medical School
Neurology, Massachusetts General Hospital
MD Boston University 1983
aging; alzheimer's disease; brain; brain aging; brain insulin resistance; cellular metabolic dsyfunction; cerebrospinal fluid; dementias; diagnosis of dementia; molecular markers; neurodegenerative diseases; postmortem brain tissue

Dr. Arnold leads a broad clinical and translational research program on Alzheimer’s disease and other neurocognitive disorders of aging. His major interests include clinicopathological correlation studies of molecular markers in human cerebrospinal fluid and postmortem brain tissue, the discovery and validation of biochemical biomarkers for diagnosis and staging of neurodegenerative dementias, and the design and conduct of novel, early phase and proof-of-concept clinical trials. Specific topics of interest in Alzheimer’s disease include laboratory and clinical research studies of brain insulin resistance and cellular metabolic dysfunction, proteomic analyses in brain tissue and cerebrospinal fluid with clinical correlation, and the neurobiological roots of neuropsychiatric dysfunction. Dr. Arnold’s work aims to accelerate therapeutics discovery and development for Alzheimer’s disease and related dementias with innovative mechanistic and biomarker-intensive clinical trials.


After receiving his M.D. from Boston University, Dr. Arnold completed residency training in Psychiatry at the New York State Psychiatric Institute/Columbia Presbyterian Medical Center in New York, and residency training in Neurology at the University of Iowa Hospitals and Clinics in Iowa City. He also completed fellowship training in Behavioral Neurology / Cognitive Neuroscience and was a post-doctoral associate in Neuroanatomy in Iowa. Dr. Arnold is board certified in both neurology and psychiatry. After his training, Dr. Arnold joined the faculty at the University of Pennsylvania where he was Professor of Psychiatry and Neurology until his move to MGH in 2015.

At MGH, Dr. Arnold is leading the Interdisciplinary Brain Center, a new collaboration of the Departments of Neurology. Psychiatry and the Martinos Center for Neuroimaging. Its mission is to facilitate the discovery, development, and implementation of promising therapeutics and associated diagnostics for individuals with complex brain disorders that affect cognition, behavior and emotion. Alzheimer's disease and related disorders are major disease interests of the Interdisciplinary Brain Center.

Research lab website Publications Clinical Profile

Wang Ambulatory Care Cntr
15 Parkman Street
Boston, MA 02114