Investigator, Other (M) Center for Genomic Medicine, Mass General Research Institute

Lecturer on Psychiatry, Part-time Harvard Medical School

Associate Member Broad Institute

epilepsy; finland; genetic predisposition to disease; genome-wide association study; migraine; migraine disorders; polymorphism single nucleotide; schizophrenia

Dr. Palotie is a faculty member at the Center for Genomic Medicine at the Massachusetts General Hospital in Boston and at the Broad Institute of MIT and Harvard and Research Director of the Human Genomics program at the Institute for Molecular Medicine Finland (FIMM) in Helsinki. Aarno received his MD and PhD degrees at the University of Oulu his specialty in Clinical Chemistry at the University of Helsinki. His past positions include professorships at the University of Helsinki, University of California Los Angeles (UCLA), Director of the Finnish Genome Centre at the University of Helsinki and a Senior Group Leader at the Wellcome Trust Sanger Institute.

The overall goal of Aarno Palotie´s group is to improve our understanding of the genetic mechanisms underlying common diseases. Much of our work draws on the unique clinical and population-based samples collected from the Finnish founder population. One of the main focus areas is genetics of neurological, neurodevelopmental and neuropsychiatric traits.

The long-lasting geographical and linguistic isolation, internal migrations, famines and rapid, recent expansions have moulded the population structure of Finland for thousands of years. Such population isolates provide exceptional opportunities for identification of genome variations underlying disease traits. When the unique population structure is combined with the one payer health care system, the harmonized training of physicians and tradition in epidemiological research Finland has become one the most interesting places for genetic epidemiology.

The availability of large sample collections, mostly performed by the Institute of Health and Welfare has stimulated large international collaborative projects such as the SISu project (Sequencing Initiative Suomi) that combines most of the large-scale sequence data produced worldwide. The aim is to construct a large genome data resource that facilitates to develop strong genome medicine programs.

Diseases of specific interest in the Palotie group are migraine, schizophrenia, epilepsy, their comorbidities and some cardiovascular traits. The wealth of multiple large study samples enables the group to use different study designs for genome variant identification and verification and for the estimation of the size of the effect contributed by the variants. These include large collaborative genome wide association (GWAs) and sequencing studies and studies that utilize family structures and extreme population bottlenecks to identify low frequency variant detection.