< Return to Find a Researcher
D. Christopher Bragg, Ph.D.
Mass General Research Institute
Assistant Professor of Neurology
Harvard Medical School
Harvard Stem Cell Institute
|PhD University of North Carolina Chapel Hill 2000
apoptosis regulatory proteins; choroid plexus; dystonia; dystonia cell culture models; dystonia musculorum deformans; dyt1; dyt6; feline acquired immunodeficiency syndrome; inclusion bodies; induced pluripotent stem cells; intracellular membranes; lymphoblasts; molecular chaperones; organelles; primary fibroblasts; thap1; x-linked dystonia parkinsonism
Research in the Bragg laboratory is directed towards the identification of pathogenic mechanisms underlying hereditary forms of dystonia and the development of screening tools to seek novel candidates for treating these disorders. Their approach involves the derivation and characterization of dystonia cell culture models, including primary fibroblasts, lymphoblasts, and induced pluripotent stem cells (iPSCs), which can be used for probing cellular defects and testing candidate therapeutics. Current projects are focused on studies of DYT1 and DYT6 dystonias, linked to mutations in TOR1A
, respectively, as well as X-Linked Dystonia-Parkinsonism (XDP), for which the genetic lesion is not yet known.