Tatsuo Kawai, M.D., Ph.D.
Physician Investigator (Cl) Surgery, Mass General Research Institute |
Professor of Surgery Harvard Medical School |
Visiting Surgeon Transplant Surgery, Massachusetts General Hospital |
MD Nihon University 1981 |
PhD Tokyo Women's Medical University 1991 |
Research Interests
Research Narrative
The induction of donor-specific tolerance is currently one of the most important goals of organ or cell transplantation.
Based on our rodent studies on mixed chimerism, we developed a clinically relevant non-myeloablative preparative regimen to induce mixed chimerism and renal allograft tolerance following donor bone marrow transplantation in MHC fully-mismatched cynomolgus monkeys. This approach has been successfully extended to HLA mismatched kidney transplant recipients.
In 4/5 recipients who were treated with our mini-bone marrow transplant, immunosuppression was successfully discontinued at 9-14 months following the transplant in the other four recipients with longest survival exceeding 7 years. Since January 2009, an expanded, multi-center clinical trial for tolerance induction following HLA mismatched kidney transplantation has been underway.
tkawai@mgh.harvard.edu |
6177260289 |
White Building 55 Fruit Street 521B Boston, MA 02114 |