Tatsuo Kawai, M.D., Ph.D.
Physician Investigator (Cl)
Surgery, Mass General Research Institute
Professor of Surgery
Harvard Medical School
Transplant Surgery, Massachusetts General Hospital
|MD Nihon University 1981|
|PhD Tokyo Women's Medical University 1991|
The induction of donor-specific tolerance is currently one of the most important goals of organ or cell transplantation.
Based on our rodent studies on mixed chimerism, we developed a clinically relevant non-myeloablative preparative regimen to induce mixed chimerism and renal allograft tolerance following donor bone marrow transplantation in MHC fully-mismatched cynomolgus monkeys. This approach has been successfully extended to HLA mismatched kidney transplant recipients.
In 4/5 recipients who were treated with our mini-bone marrow transplant, immunosuppression was successfully discontinued at 9-14 months following the transplant in the other four recipients with longest survival exceeding 7 years. Since January 2009, an expanded, multi-center clinical trial for tolerance induction following HLA mismatched kidney transplantation has been underway.