Benjamin Kleinstiver, Ph.D.


Assistant Investigator
Center for Genomic Medicine, Mass General Research Institute
Assistant Professor of Pathology
Harvard Medical School
Temporary Academic
Pathology, Harvard Medical School
Kayden-Lambert MGH Research Scholar 2023-2028
Mass General Research Institute, Massachusetts General Hospital
crispr; dna; dna breaks double-stranded; dna breaks single-stranded; dna cleavage; endodeoxyribonucleases; endonucleases; evolution molecular; genetic therapy; genome bacterial; genome editing; protein engineering

Genome editing technologies offer hope for the correction of disorders that are the result of mutations in a patient’s DNA. Dr. Kleinstiver's research group pursues protein engineering strategies to improve important properties of CRISPR genome editing enzymes (including their activities, specificities, and targeting ranges, etc.), to develop new genome editing methods, and also explores the feasibility of applying these engineered technologies for the treatment of genetic diseases. 

Dr. Kleinstiver is a Principal Investigator in the Center for Genomic Medicine at the Massachusetts General Hospital (MGH) and Harvard Medical School (HMS).

Research in the Kleinstiver laboratory is supported by an NIH DP2 New Innovator Award, as a co-PI/co-I on other NIH awards, an MGH Research Scholar Award, an MGH ECOR Howard M. Goodman Award, CHDI, the Blavatnik Foundation, the Gilbert Foundation, and Angea Biotherapeutics.

Visit the Kleinstiver Lab website at www.kleinstiverlab.org.

Research website Publications
bkleinstiver@mgh.harvard.edu
(617) 724-6057
Center for Genomic Medicine
Simches Building
185 Cambridge Street
5th Floor
Boston, MA 02114-2790