Benjamin Kleinstiver, Ph.D.

Assistant Investigator
Center for Genomic Medicine, Mass General Research Institute
Assistant Professor of Pathology
Harvard Medical School
dna breaks, double-stranded; dna breaks, single-stranded; dna cleavage; endodeoxyribonucleases; endonucleases; genome, bacterial

Genome editing technologies offer hope for the correction of disorders that are the result of mutations in a patient’s DNA. Dr. Kleinstiver's research group pursues protein engineering strategies to improve important properties of CRISPR genome editing nucleases (including their activities, specificities, and targeting ranges), while also exploring the feasibility of applying these engineered technologies for the treatment of genetic diseases.

Dr. Kleinstiver is a Principal Investigator in the Center for Genomic Medicine at the Massachusetts General Hospital (MGH) and Harvard Medical School (HMS).

Research in the Kleinstiver laboratory is supported by an NIH DP2 New Innovator Award, as a co-PI/co-I on other NIH awards, an MGH ECOR Howard M. Goodman Award, CHDI, the Blavatnik Foundation, and the Gilbert Foundation.

Visit the Kleinstiver Lab website at

Research website Publications
(617) 724-6057
Center for Genomic Medicine
Simches Building
185 Cambridge Street
5th Floor
Boston, MA 02114-2790