Investigator, Asst Prof (M) Athinoula A. Martinos Center for Biomedical Imaging, Mass General Research Institute

Assistant Professor of Radiology Harvard Medical School

dynamic modeling of imaging signals; models chemical; molecular imaging; mr; multi-modal imaging; neurochemistry; neuroreceptors; pet; proteins; receptors dopamine d2; receptors dopamine d3; sequence analysis protein; whole brain function

I pursue an integrated approach to non-invasively image the brain. My goal is to develop in vivo molecular and functional imaging techniques in order to build a molecular-level understanding of whole-brain function, physiology and networks. While my research is driven by neuroscientific or clinical questions, my approach uses technical expertise and quantitative approaches.

Specifically, my research focuses on (i) creating novel multi-modal experimental imaging techniques for imaging neuroreceptors in the living brain (ii) developing biomarkers through quantitative biophysical and biochemical models and (iii) apply these methods to investigate the interplay between neurochemistry and neural circuit function, or dysfunction, in the living brain. Ultimately, my goal is to translate these non-invasive techniques into the clinic to advance diagnosis and treatment of brain disorders.

Some of my key research areas in multi-modal imaging with combined PET and functional MRI are:

• Imaging neuroreceptor function
• Dynamic modeling of imaging signals
• Advancing PET/MR imaging techniques