Vibha Singhal, MD, MBBS

Physician Investigator (Cl)
Pediatric Endocrinology Program and Diabetes Center, Mass General Research Institute
Assistant Professor of Pediatrics
Harvard Medical School
MPH 2020
MBBS All India Institute of Medical Sciences 2002
adipose tissue brown; anorexia nervosa; athletic amenorrhea; bone metabolism; estrogen treatment; hypogonadism; hypothalamo-hypophyseal system; igf-1 replacement; marrow fat changes; neuroendocrine alterations; obesity; pituitary-adrenal system

My research interests include evaluation of bone outcomes in extremes of spectrums — anorexia nervosa to severe obesity. I am also interested in evaluating the role of different fat depots — visceral, subcutaneous, marrow and brown fat and their contribution to bone and metabolic consequences in various disease states like athletic triad and anorexia.

My recent work focuses on evaluating metabolic changes that happen after bariatric surgery in adolescents and the potential mechanisms contributing to those changes.

Current Research Projects

Metabolic outcomes of bariatric surgery in adolescents

Beta-cell function after sleeve gastrectomy

Bone metabolism, neuroendocrine alterations and regional fat alterations in nutritional disorders including obesity, anorexia nervosa, and athletic amenorrhea.

Marrow fat changes in girls with anorexia nervosa and evaluating changes after estrogen and IGF-1 replacement