Mikhail Papisov, Ph.D.

Radiology, Mass General Research Institute
Associate Professor of Radiology
Harvard Medical School
Research Staff
Radiology, Massachusetts General Hospital
M.S. Moscow State University 1982
PhD USSR Cardiology Research Center 1988
central nervous system diseases; drug delivery systems; drug development; drug targeting; gene therapy; lymphatic system; macromolecular drugs; pet; pharmacological imaging
My research is focused on identifying novel aspects of the in vivo transport mechanisms. When such aspects are identified, designing macromolecular therapeutic constructs optimized to “ride” on these novel mechanisms to their respective targets. 

Accordingly, the research activities of my lab include:
  • Investigation of in vivo transport processes, using novel PET/CT-based methods
  • Development and characterization of macromolecular and supramolecular therapeutics utilizing the newly discovered transport mechanisms
  • Development of accessory technologies for assembling macromolecular therapeutics, including novel fully biodegradable "stealth" biomaterials

The current research focus is on the perivascular transport of macromolecules in the CNS and barrier-free delivery of therapeutics to the CNS.