Daniel Hamilos, M.D.
Physician Investigator (Cl)
Allergy and Clinical Immunology Unit, Mass General Research Institute
Associate Professor of Medicine
Harvard Medical School
Allergy and Clinical Immunology Unit, Massachusetts General Hospital
|MD Northwestern University Medical School 1979|
My laboratory is investigating the pathogenesis of chronic rhinosinusitis (CRS). We are examining whether the nasal/sinus epithelium of CRS patients is lacking in the ability to produce innate immune factors involved in defense against infection.
We are examining nasal/sinus tissue samples as well as cultured epithelial cells. We are currently examining innate immune and inflammatory gene expression in nasal/sinus tissues using broad-based mRNA expression profiling. These studies are supported by a grant from the Flight Attendants Medical Research Institute (FAMRI) as well as a Harvard Catalyst Grant. It is our hope that these studies will lead to a greater understanding of CRS pathogenesis and help identify novel therapies.
I am also a co-investigator with Dr. Andrew Luster in an NIH funded project aimed at understanding the role of chemokines and Th2 cellular trafficking in asthma. I am responsible for recruitment and preparation of subjects for bronchoscopy and bronchoalveolar lavage. Each subject's allergic sensitivity to house dust mite and cat allergen is first determined by skin test titration.
Subsequently, each subject undergoes bronchoscopy with seqmental allergen challenge followed 24 hours later by bronchoscopy with bronchoalveolar lavage. We are also comparing the inflammatory response to allergen in allergic nonasthmatics versus allergic asthmatics to determine whether cellular inflammation can account for the asthmatic response. It is our hope that these studies will help elucidate the mechanisms that control the asthmatic response and the link between allergic airway inflammation and airway hyperesponsiveness.