Casey Maguire, Ph.D.

Associate Investigator
Neurology, Mass General Research Institute
Associate Professor of Neurology
Harvard Medical School
adeno-associated virus vectors; capsid proteins; copepoda; dependovirus; exosomes; fireflies; gene therapy; gene transfer techniques; genetic vectors; luciferases; luminescent measurements; transduction genetic; transport vesicles; viral vectors

The main focus of the Maguire lab is the development of more potent and safer  gene delivery systemS to answer therapeutic challenges of today and tomorrow. One such technology is called exo-AAV. exo-AAV are enveloped adeno-associated virus (AAV) vectors. The envelope is derived from exosomes which are  lipid based nanoparticles released by cells. Exosomes have several properties which may enhance AAV-mediated gene delivery.

Research website Publications

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