Youssef Jounaidi, Ph.D.
Instructor in Investigation
Anesthesia, Critical Care and Pain Medicine, Mass General Research Institute
Instructor in Anaesthesia
Harvard Medical School
Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
|PhD University of Montpellier II 1995|
Recently, we further improved our platform to include signaling from both IL2 and IL21 in a single chimeric construct that achieves superior anti-cancer activity. We have also engineered a novel soluble form of IL2 that is fourfold more potent and longer acting than wild-type IL2 in activating natural killer cells and T cells. Therefore, our translational approaches are aiming to use engineered chimeric cytokines either as cell membrane attached or soluble to empower cancer immunotherapy.
Current cancer immunotherapy strategies using T-cells and NK cells are encountering several obstacles. Among these are the inefficacy against solid tumors and the exhaustion of immune cells after encountering cancer cells. Our cancer immunotherapy platform is optimized to specifically resolve these issues.