Clinicn Investigator, Assc Prf PATHM RSCH FAC, Mass General Research Institute

Associate Professor of Pathology Harvard Medical School

Thomas F. and Diana L. Ryan MGH Research Scholar 2019-2024 Mass General Research Institute, Massachusetts General Hospital

Associate Molecular Pathologist Pathology, Massachusetts General Hospital

Associate Member Broad Institute

MD Harvard Medical School 2001

chromosomes human; epigenetics; genes wilms tumor; hepatoblastoma; kidney neoplasms; oncogene proteins fusion; pediatric oncology; pediatric tumors; proto-oncogene protein c-fli-1; rna-binding protein ews; tumor suppressor proteins; wilms tumor; wt1 proteins Pediatric tumors are often driven by mutations in genes that directly control gene expression programs such as transcription factors and chromatin regulators. Our laboratory uses genomic technologies to identify abnormal gene regulation patterns in tumors and to analyze critical oncogenic pathways in several systems. Given that the mechanisms that drive pediatric tumors are poorly understood at present, we anticipate that our work will point to new therapies for these diseases.