Physician Investigator (Cl) ID Research 2 Monthly, Mass General Research Institute

Associate Professor of Medicine Harvard Medical School

Associate Physician Infectious Disease, Massachusetts General Hospital

MD Harvard Medical School 1997

MD 1997

antiviral agents; cd8-positive t-lymphocytes; cell-mediated immunity; drug resistance viral; hepacivirus; hepatitis c; hepatitis c chronic; hepatitis c virus; immune-mediated viral evolution; rna viral; substance abuse intravenous

My research interests are related to hepatitis C virus (HCV) infection in special populations. I have three primary areas of focus:

1. HCV in immunosuppressed humans, including coinfection with HIV-1 and post-transplantation.  My interests are in cell-mediated immunity and HCV viral evolution in collaboration with Georg Lauer, Todd Allen

2. Immunology of acute HCV, in collaboration with Georg Lauer of the Gastrointestinal Unit

3. Acute HCV in the MA prisons.  As project leader of a U19 NIH Center Grant, I am studying acute HCV in the Massachusetts State Prisons in collaboration with Barbara McGovern at the Lemuel Shattuck Hospital and the Department of Public Health

4. Immunogenetics of HCV infection, in collaboration with Georg Lauer, Ray Chung of the Gastrointestinal Unit, and Mark Daly of the Broad Institute