Claudio Vinegoni, Ph.D.
Center for Systems Biology, Mass General Research Institute
Assistant Professor of Radiology
Harvard Medical School
Radiology, Massachusetts General Hospital
|PhD University of Geneva School of Medicine 2002|
The current research activity involves the development of novel optical mesoscopic molecular imaging techniques that allow to generate in-vivo three-dimensional data in optically diffusive non-transparent living organisms with a size up to a few millimeters (e.g. Drosophila Melanogaster, Zebrafish) providing both in-vivo anatomical and functional imaging.
At the same time we are committed into the development of new fluorescence molecular tomography (FMT) techniques in diffusive regime for whole mouse imaging. Other research activities involve in vivo near infrared fluorescence imaging of protease activity in rabbit models of atherosclerosis and the development of novel fiber based imaging systems, and the development of combined optical and opto-acoustic multispectral tomographic imaging for in-vivo imaging applications.
Other macro and mesoscopic imaging technique are pursued such as Born normalized Optical Projection Tomography with molecular contrast for ex-vivo small animal and whole organ imaging. This technique provides detailed tomographic reconstruction of morphology and molecular probes within tissue with resolution up to 5 microns in entire organs (e.g. heart, brain, kidney, etc) and can complement in-vivo imaging techniques such as FMT and MPM.
We are developing new applications for novel microscopy imaging systems and design and conduct cutting-edge experiments. In particular we are interested in providing new techniques for motion compensation for multiphoton microscopy in order to avoid artifacts due to respiratory and cardiac motion. Both hardware and software based approaches are conducted.