Jonathan Hoggatt, Ph.D.

Instructor in Investigation
Center for Transplantation Sciences, Mass General Research Institute
Assistant Professor of Medicine
Harvard Medical School
Principal Faculty
Harvard Stem Cell Institute
Cancer Center, Massachusetts General Hospital
PhD Indiana University School of Medicine 2010
bone marrow cells; cannabinoids; cell movement; dinoprostone; engraftment; granulocyte colony-stimulating factor; hematopoiesis; hematopoietic stem cell mobilization; hematopoietic stem cell transplantation; hematopoietic stem cells; stem cell niche

The Hoggatt Laboratory is broadly interested in the stem cell niche regulatory mechanisms that govern tissue regeneration, particularly regulation by macrophages. The lab also has a specific interest in translational science for bone marrow transplantation and other treatments. The laboratory has identified a unique “highly engraftable” hematopoietic stem cell that is currently being investigated and has applications for further probing of stem cell niche biology and clinical applications in stem cell transplantation, gene therapy, and other fields. The lab has also developed unique genetic mouse models allowing for the dynamic exploration of macrophage heterogeneity in a variety of disease settings.

Research efforts over the last several decades working to develop therapies have largely focused on finding “magic bullets”, a small molecule or perhaps protein biologic that can be given to a patient as a drug to cure their disease.

We believe the that the cures of the future will come from tapping in to the body’s natural regenerative capacities, or will use cellular therapies, namely stem cell transplantation. Our goal is to discover new regenerative pathways within the body to allow for disease correction and to make stem cell transplantation faster, safer, cheaper, and better to broaden its use to more patients.

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Research website Publications

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