Kyle Lillis, Ph.D.


Instructor in Investigation
Neurology, Mass General Research Institute
Term Lecturer, IHP
Center for Interprofessional Studies and Innovation, Massachusetts General Hospital
Instructor in Neurology
Harvard Medical School
Research Staff
Neurology, Massachusetts General Hospital
PhD Boston University 2009
brain networks; epilepsy; epileptogenesis; hippocampus; interneurons; microscopy fluorescence; multiphoton; neural networks; pediatric epilepsy; pyramidal cells; seizures

Our long-term research goal is the development of new approaches to the treatment of epilepsy based on a clearer understanding of the necessary steps in seizure initiation and propagation.

The two major themes in the lab are neuronal ion transport and the spread of activity in neural networks. Neuronal ion transport underlies signaling at all fast synapses. The importance of neuronal ion transport was underscored by our recent discovery that reversed ion transport in the immature brain was blocking the effects of the anticonvulsants most commonly used to treat neonatal seizures, and that a safe and well-characterized diuretic could ameliorate this condition.

Our work on the spread of excitation in neural networks combines fluorescent imaging of network activity with computerized analysis and modeling to understand how normal and abnormal signaling progresses through neural networks. We have found evidence for reentrant or circular patterns of neural activity that resemble cardiac fibrillation and precede seizures. We are currently testing whether this reentrant activation of neural circuits is the earliest stage of a seizure, and the stage at which intervention is most effective. We are also testing whether long-term reductions in the strength of synaptic connections between neurons in epileptic networks can reduce the probability of seizures.

Pediatric Epilepsy Research Lab: Kevin J. Staley Lab Publications
klillis@mgh.harvard.edu
Pediatric Epilepsy Research Lab
CNY-Building #114
114 16th Street
Charlestown, MA 02129-2000