Johannes Van Agthoven, Ph.D.
Instructor in Investigation
Nephrology, Mass General Research Institute
Instructor in Medicine
Harvard Medical School
Nephrology, Massachusetts General Hospital
|PhD Paris V University 2010|
A major research goal of the Arnaout Laboratory is to elucidate the structure and function of integrins, cell adhesion receptors that play vital roles in normal physiology and disease, and use the derived information in structure-based design of new and safer anti-integrin drugs targeting heart disease, fibrosis, and cancer.
Other research interests include elucidating mechanisms underlying cyst formation in Autosomal Dominant Polycystic Kidney Disease, transcriptional regulation of hematopoiesis, mechanisms of kidney regeneration, and design of microfluidic dialysis devices.