Andrea McClatchey, Ph.D.
Center for Cancer Research, Massachusetts General Hospital
Professor of Pathology
Harvard Medical School
Patricia and Scott Eston MGH Research Scholar (2011-2016)
Mass General Research Institute, Massachusetts General Hospital
|PhD Harvard University 1993|
The McClatchey laboratory seeks to understand how cells organize their outer membrane or cortex, which, in turn, determines their identity, behavior, and interface with the external environment. Cancer cells exhibit defective membrane organization and therefore interact inappropriately with other cells and with their environment.
Our research stems from a longstanding dedication to understanding the molecular basis of neurofibromatosis type 2 (NF2), a familial tumor syndrome caused by mutation of the NF2 tumor suppressor gene. The NF2-encoded protein, Merlin, and closely related ERM proteins (Ezrin, Radixin, and Moesin) are key architects of the cell cortex.