David Ting, M.D.

Physician Investigator (Cl)
Cancer Center, Mass General Research Institute
Associate Professor of Medicine
Harvard Medical School
Assistant Physician
Medicine-Hematology/Oncology, Massachusetts General Hospital
MD 2004
cancer; cancer biomarkers; gene transfer techniques; hematopoiesis; hematopoietic stem cells; liver cancer; microfluidics; non-coding rnas; pancreatic cancer; pluripotent stem cells; rnas; transgenes Pancreatic and liver cancers are highly lethal cancers where the vast majority of patients are diagnosed too late and conventional therapies have largely been ineffective, making early detection and novel drug targets greatly needed. Recently, a significant amount of “non-coding” repeat RNAs have been found to be produced in high amounts at the earliest stages of cancer development, but not in normal tissues. Interestingly, these satellite RNAs appear to activate a viral response program that appears to help cancers prevent immune cells from attacking them. The Ting Laboratory has been utilizing innovative microfluidic chip technologies to capture circulating tumor cells (CTCs) and have used satellite RNAs to develop novel blood based early detection biomarkers of cancer. In addition, we are uncovering how these repeat RNAs alter the immune response as a novel immunotherapy target.
Research website Publications

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