Shobha Vasudevan, Ph.D.

Associate Investigator
Center for Regenerative Medicine, Massachusetts General Hospital
Associate Professor of Medicine
Harvard Medical School
Research Staff
Cancer Center, Massachusetts General Hospital
Principal Faculty
Harvard Stem Cell Institute
PhD University of Medicine and Dentistry of New Jersey 2003
3' untranslated regions; cancer quiescence; chemoresistance; micrornas; post-transcriptional regulation; protein synthesis; ribonucleoproteins; ribosomes; rna modifications; rna-binding proteins; stress signaling The Vasudevan laboratoryfocuses on the role of post-transcriptional mechanisms in clinically resistant quiescent cancer cells. Tumors demonstrate heterogeneity, harboring a small subpopulation that switch from rapid proliferation to a specialized, reversibly arrested state of quiescence that decreases their susceptibility to chemotherapy. Quiescent cancer cells resist conventional therapeutics and lead to tumor persistence, resuming cancerous growth upon chemotherapy removal. Our data revealed that post-transcriptional mechanisms are altered, with modification of noncoding RNAs, associated complexes and ribosomes—molecules that control vital genes in cancer—which are important for the persistence of quiescent cancer cells.
Vasudevan Lab Publications

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