Mikael Pittet, Ph.D.
Center for Systems Biology, Mass General Research Institute
Professor of Radiology
Harvard Medical School
Samana Cay MGH Research Scholar 2015-2020
Mass General Research Institute, Massachusetts General Hospital
|PhD University of Lausanne School of Medicine 2001|
My laboratory performs research on the host immune response in vivo. We aim to understand better where, when and how immune cells are produced, traffic, and mediate regulatory or effector functions.
For example, our recent work has identified new information on the origins, mobilization and amplification of innate immune cells known as monocytes. We have also started to define some aspects of the functional relevance of these cells in enhancing or suppressing inflammation.
Our next goal is to better understand the responses mediated by monocytes and other host cells in response to various forms of cancers or other inflammatory diseases. Experimental and clinical evidence indicates that diverse populations of immune cells infiltrate the tumor stroma and enhance cancer progression.
We aim not only to understand how tumors are able to co-opt tumor-promoting immune cells—both locally and remotely––but also whether new cancer molecular and cellular targets may prove valuable in the diagnosis and treatment of the disease.
To contribute a more dynamic understanding of immune reactions in the body, we examine the behavior and functions of cells by combining several experimental tools. These include classic molecular and cellular techniques, microsurgical procedures and in vivo imaging modalities.
In vitro readouts do not always recapitulate the complexity of in vivo environments, thus we use real-time imaging technologies, which permit to assess the immune system quantitatively and in living subjects. We collaborate with various CSB investigators and with other laboratories in Boston, the U.S., and abroad.
Follow the Pittet Lab on Twitter @PittetLab