Jeannie Lee, M.D., Ph.D.
Department of Molecular Biology, Massachusetts General Hospital
Physician Investigator (NonCl)
M_MOLBIO FACULTY, Mass General Research Institute
Professor of Genetics
Harvard Medical School
Howard Hughes Medical Institute
Harvard Stem Cell Institute
Researchers in the Lee Lab use state-of-the-art technologies in molecular biology, biochemistry, cell biology, and embryology to understand how one X-chromosome is turned off in the female but not in the male.
Our lab studies how male (XY) and female (XX) cells use a mechanism called X-chromosome inactivation to achieve equality of sex chromosome gene expression.
Our studies are focused on three noncoding RNA loci whose actions coordinate the many steps of X-chromosome inactivation. We are also interested in the mechanistic and evolutionary relationship between X- inactivation and imprinting. Recent work by the Lee Lab suggests that imprinted X-chromosome inactivation is directly connected to meiotic sex chromosome inactivation in the male germ line.