Physician-Investigator Department of Molecular Biology, Massachusetts General Hospital

Chair, Molecular Biology M_MOLBIO FACULTY, Massachusetts General Hospital

Professor of Genetics Harvard Medical School

Investigator Howard Hughes Medical Institute

Affiliate Faculty Harvard Stem Cell Institute

Associate Member Broad Institute

chromatin; chromatin modifiers; dosage compensation genetic; epigenesis genetic; epigenetics; genomic imprinting; lncrnas; long non-coding rnas; muscular dystrophy; rett syndrome; rna long untranslated; rna untranslated; transcriptomes; x chromosome; x chromosome inactivation; x-inactivation center; xci

Researchers in the Lee Lab use state-of-the-art technologies in molecular biology, biochemistry, cell biology, and embryology to understand how one X-chromosome is turned off in the female but not in the male.

Our lab studies how male (XY) and female (XX) cells use a mechanism called X-chromosome inactivation to achieve equality of sex chromosome gene expression.

Our studies are focused on three noncoding RNA loci whose actions coordinate the many steps of X-chromosome inactivation. We are also interested in the mechanistic and evolutionary relationship between X- inactivation and imprinting. Recent work by the Lee Lab suggests that imprinted X-chromosome inactivation is directly connected to meiotic sex chromosome inactivation in the male germ line.