Chief of Service Massachusetts General Hospital

Professor of Genetics Harvard Medical School

Associate Member Broad Institute

PhD UC Berkeley 1981

adenosine triphosphatases; chromatin; chromatin assembly and disassembly; chromosomal proteins non-histone; drosophila proteins; epigenetics; histones; nucleosomes; transcription factors

What we do: This lab is interested in understanding the fundamental mechanisms of how eukaryotic enzymes can modify chromatin. One focused approach is to isolate chromatin-modifying proteins and to test such complexes in functional assays, with the thesis that assay outcomes will inform the in vivo function of these protien machines. Another important goal is to understand how long-range chromatin interactions are established in the cell nucleus, and this effort is leading to new strategies towards defining such interactions in vivo.