Marcia Goldberg, M.D.

Physician Investigator
Infectious Disease, Massachusetts General Hospital
Physician Investigator (Cl)
Infectious Disease, Mass General Research Institute
Professor of Medicine
Harvard Medical School
Infectious Disease, Massachusetts General Hospital
Associate Member
Broad Institute
MD Harvard Medical School 1984
actins; bacterial outer membrane proteins; bacterial proteins; dysentery bacillary; escherichia coli; escherichia coli proteins; innate immunity; sepsis; shigella; shigella flexneri

Our research focuses on the interface of bacterial pathogens with human cells. Most gram-negative bacterial pathogens use specialized secretion systems (“type 3 secretion systems”) to deliver virulence proteins into human cells during infection. The proteins that are delivered by this means (“effector proteins”) manipulate human signaling pathways, cytoskeletal dynamics, and innate and adaptive immune responses, in ways that promote disease. These effector proteins are absolutely necessary for disease. Using genome-wide screens, we identified human signaling pathways required for infection by the gram-negative bacterial pathogen Shigella flexneri. Shigella are important human pathogens that cause diarrhea and dysentery, predominantly in daycare centers, institutions, and developing regions of the world. We also discovered and are investigating mechanisms critical to the innate immune response to bacteria, including during sepsis, a dysregulated innate immune response to bacterial infection in humans.

We investigate:

  1. The molecular mechanisms by which bacterial effector proteins alter cellular targets and cellular signaling pathways
  2. The mechanisms by which human signaling pathways identified in our screens contribute to infection
  3. The mechanisms of immune dysregulation in human sepsis
Research lab website Publications Clinical Profile
(617) 525-4820
Infectious Disease
Harvard Institutes of Medicine
4 Blackfan Circle,
8th floor / Room 847
Boston, MA 02115-5713