Bobby Cherayil, MBBS, MD
Physician Investigator (NonCl)
Mucosal Immunology and Biology Research Center, Mass General Research Institute
Associate Professor of Pediatrics
Harvard Medical School
|MBBS Christian Medical College University of Madras 1981|
The broad goal of research in my laboratory is to understand the cellular and molecular mechanisms involved in the immune response to intestinal bacterial pathogens. We use cell culture and mouse infection experiments to interrogate the responses of intestinal epithelial cells and macrophages to Salmonella Typhimurium, an important cause of acute gastroenteritis in humans and also representative of the agent of human typhoid fever. We are particularly interested in the interactions between these responses and the metabolism of nutrients such as iron. Our studies (i) shed light on basic immunological mechanisms operating in the gastrointestinal tract, (ii) provide insights into the pathogenesis of intestinal infections that are of public health significance, particularly in the developing world, (iii) inform strategies to develop vaccines against the pathogens that cause these infections, and (iv) clarify how iron status can affect the course of infection and how infection and inflammation can influence iron metabolism.