Amy Barczak, M.D.

Physician Investigator (Cl)
Ragon PIs 1, Mass General Research Institute
Associate Professor of Medicine
Harvard Medical School
Assistant Physician
Infectious Disease, Massachusetts General Hospital
Associate Member
Broad Institute
MD 2004
anti-bacterial agents; antigens bacterial; cellular models of infection; cyclic amp response element-binding protein; microbial sensitivity tests; mycobacterial; mycobacterium; mycobacterium smegmatis; mycobacterium tuberculosis; phagosomes; rna; tuberculosis; tuberculosis pulmonary; urine; virulence; virulence factors; virulence lipids

The Barczak laboratory is interested in understanding the TB host-pathogen interface as a means to developing novel therapeutic approaches to treating TB.

We currently have three areas of interest:

  1. Identifying and characterizing mycobacterial factors required for survival and virulence in cellular models of infection, with a particular focus on virulence lipids.
  2. Developing novel approaches to screening for compounds with anti-TB activity in the host.
  3. Using mycobacterial genetic tools to explore the host response to infection.
Research lab website Publications Clinical Profile

400 Tech Square
400 Technology Square
Cambridge, MA 02139