Clinician Investigator, Full Professor Genetics Program, Mass General Research Institute

Professor of Pediatrics, Part-time Harvard Medical School

Pediatrician Pediatrics-Genetics, Massachusetts General Hospital

MD Jefferson Medical College 1980

cardiovascular abnormalities; costello syndrome; heart defects congenital; macrocephly-capillary malformation; myhre syndrome; rasopathy syndromes; smad4 mutations; turner syndrome

Angela E. Lin, MD is a Board-certified pediatrician and clinical geneticist who is dedicated to the care of people with physical differences, especially syndromes which involve the cardiovascular system. She is active in numerous research projects, and has published over 100 articles and chapters. She is committed to teaching families and trainees.

Dr. Lin attended St. Joseph's University and Thomas Jefferson University in Philadelphia, and completed a pediatric residency at Children's Hospital of Pittsburgh. After a fellowship in pediatric cardiology at UCLA, and additional training at the Children's Hospital of Philadelphia, she completed a genetics fellowship at the West Penn Hospital in Pittsburgh. From 1990-1994, she worked at the National Birth Defects Center in Boston. After a maternity leave, she joined the Massachusetts General Hospital in 1997, where she is a Staff Geneticist, and a Professor in Pediatrics, Part-Time at Harvard Medical School.

Dr. Lin is passionate about providing care coordination for people and families with rare genetic syndromes.  In 2011, she and Dr. Lynne Levitsky started the multi-specialty Turner Syndrome Clinic, joined in 2012 by Dr. Frances Hayes (REU). As of 2024, they have evaluated over 350 patients as the largest Turner syndrome program on the east coast, and have expertise in help young women transition to adult care.  Dr. Lin has been a member of the Professional Advisory Board of the Turner Syndrome Society of the United States for 10 years. She participated in the International Conferences which updated the Clinical Guidelines in 2017 and 2023. 

Dr. Lin co-founded the MGH HHT Center in 2010, and directs the pediatric and genetics sections of the MGH Center of Excellence.

In 2016, she founded the MGH Myhre Syndrome Clinic with Dr. Mark Lindsay from pediatric cardiology. This is the sole clinic of its kind in the world providing multi-specialty care across the lifespan. A review describing the emerging natural history of 47 patients (2024) and they are on track to see 60 patients in 2025.

Her decades long interest cardiogenetics service includes patients with "RASopathy" syndromes (especially Costello syndrome) and CHARGE syndrome. Dr. Lin also evaluates people with craniofacial disorders, vascular anomaly syndromes, and Sotos syndrome.  

Dr. Lin serves as a research consultant in the field of birth defects surveillance at the MA Dept. of Public Health, Birth Defects Monitoring Program. She was an Associate Editor of the American Journal of Medical Genetics until 2016, and remains on the Editorial Board.